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OrganOx

start up
United Kingdom - Oxford, Oxfordshire
  • 18/07/2023
  • Unknown
  • $32,715,000

"Living Organs For Life"​
Transforming transplantation with the OrganOx metra®. A transportable, automated ex vivo liver perfusion device.

The core technology employed by the OrganOx metra® has been in development for over 15 years. During this time both of the founders (Professor Peter Friend and Professor Constantin Coussios) have driven the development of organ preservation and maintenance, formerly at the University of Cambridge and latterly at the University of Oxford.

OrganOx Limited was founded in April 2008 as a spin-out from the University of Oxford.

Conventional cold preservation involves storage of the liver at 4˚C, using a non-physiological perfusion solution that aims to minimise liver decay. By contrast, warm preservation seeks to re-create an environment that mimics the human body by continuously perfusing at physiological pressures and flows with oxygen-carrying red cells at 37˚C and providing nutrition. The liver is therefore functional during the preservation period, producing bile, metabolizing glucose and maintaining a physiological pH. This enables objective assessment of organ performance prior to transplant, extended preservation times, and the potential use of organs that are presently being discarded.


Related People

Constantin CoussiosFounder

Constantin Coussios United Kingdom - Greater Oxford Area

Professor Constantin Coussios OBE FREng is the Director of the Institute of Biomedical Engineering at the University of Oxford. He holds BA, MEng and PhD degrees in Engineering from the University of Cambridge and was elected to the first statutory chair in Biomedical Engineering at the University of Oxford in 2011. In 2008, he was one of two academic founders of Oxford University spin-out OrganOx Ltd., which has developed a novel normothermic perfusion device for improved liver preservation prior to transplantation through to randomized controlled trials, regulatory approval and commercialization in both Europe and North America. In 2014, he was the lead academic founder of OxSonics Therapeutics, developing a new generation of ultrasound-based medical devices for drug delivery that is currently undergoing first-in-human trials. In 2016, he co-founded OrthoSon Ltd, commercializing a novel technique for percutaneous minimally invasive removal and motion-restoring replacement of the intervertebral disc.
At the University of Oxford, in 2004 he founded and heads the Biomedical Ultrasonics, Biotherapy and Biopharmaceuticals Laboratory (BUBBL). In 2021, he became the Founding Director of the Podium Analytics Institute for Youth Sports Medicine and Technology, dedicated to the understanding and prevention of lifelong injury in young athletes.
Prof. Coussios received the UK’s Institute of Acoustics’ Young Person’s Award for Innovation in Acoustical Engineering in 2007, was elected as Secretary-General of the International Society for Therapeutic Ultrasound between 2006-2010 and was honoured with the Society’s Fred Lizzi award in 2012. He was elected as the youngest ever Fellow of the Acoustical Society of America in 2009, and received the Society’s Bruce Lindsay award in 2012. He received the Silver Medal of the Royal Academy of Engineering in 2017 and became a Fellow of the Academy in 2019, for his contributions to the invention and translation of novel therapeutic technologies into clinical practice. He was awarded an OBE for services to biomedical engineering in the Queen's 2022 Jubilee Birthday Honours.