Crystalys Therapeutics

- 01/10/2025
- Series A
- $205,000,000
Crystalys is a clinical-stage biopharmaceutical company transforming the treatment of gout. Co-founded by Novo Holdings and Catalys Pacific, Crystalys brings together a world-class team with deep expertise in gout drug development, dedicated to delivering more effective options for people living with gout.
Dotinurad, the company’s lead candidate and next-generation URAT1 inhibitor with best-in-class potential for safety and efficacy, is being advanced into global Phase 3 trials as a second-line therapy for gout, supported by extensive clinical data from approvals in multiple Asian markets.
- Industry Biotechnology Research
- Website https://crystalystx.com/
- LinkedIn https://www.linkedin.com/company/crystalys-therapeutics/
Related People
James MackayCo Founder

Distinguished scientist and global life sciences business leader with strong record of bringing multiple drugs to market and patients
|| Strategic thinker with ability to define and implement strategic vision through clear communication and innovative operational delivery
|| Develops strategic and operational partnerships, and builds inspiring cultures via authenticity, development of mutual trust, empowerment and mentoring
|| Creates transparent and open environments allowing staff to raise concerns, cultivating deep thinking, and achieving breakthrough results
|| Experience running large pharmaceutical and small biotechnology businesses with ability to work across international boundaries and cultures, enhancing delivery through diversity
|| Value-driven decision making, the courage to make tough decisions to achieve value-added delivery to the business, and a purposefulness and drive to deliver an outcome that creates positive and lasting change
CAREER HIGHLIGHTS
• Led successful $1.2B acquisition and transition of Ardea Biosciences into AstraZeneca
• Achieved FDA and EMA approval of Zurampic, the first novel MOA for the treatment of gout
in over 50 years
• Led successful commercial licensing of Zurampic and Duzallo to Ironwood Pharmaceuticals and
Grunenthal
• Transformed the AstraZeneca/BMS Diabetes global development and commercial collaboration, and
established Onglyza, Kombiglyze XR and Komboglyze as key growth drivers in the AZ portfolio
• Designed and implemented multiple innovative delivery and partnership models including an
industry leading approach to delivery of outsourced clinical work through development of strategic
partnerships with CROs
• Designed and implemented multiple strategic re-organizations, led major global change
management, whilst delivering improved efficiencies and productivity